Background: Zinc, an essential element required for cell proliferation and differentiation, plays a role in a diverse array of cellular functions (such as neuroregulation) and acts as a cofactor for numerous enzymes and transcription factors. The zinc transporter (ZnT) family regulates the supply of zinc within cells, and its members commonly contain six membrane-spanning domains, a large histidine-rich intracellular loop and a C-terminal tail. ZnT-6 (Zinc transporter 6), also known as SLC30A6 (Solute carrier family 30 member 6), is a 461 amino acid gene product that localizes to the membrane of the trans-Golgi network. Expressed throughout the body with highest expression in brain, eye and lung, ZnT-6 functions as zinc transporter that regulates zinc homeostasis within vesicular compartments and the Golgi apparatus and may help to form insulin crystals within pancreatic beta cells. ZnT-6 is expressed as three isoforms due to alternative splicing events and its expression is upregulated in response to zinc depletion.
Description: Rabbit polyclonal to ZNT6
Immunogen: KLH conjugated synthetic peptide derived from ZNT6
Specificity: ·Reacts with Human, Mouse and Rat.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 51 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
