Background: The human DLK gene maps to human chromosome 14q32 and encodes a 383 amino acid protein. DLK, also designated preadipocyte factor 1 (pref-1), ZOG, pG2 or FA1, is a transmembrane protein with six tandem EGF-like repeats in the putative extracellular domain, which is characteristic of the EGF-like protein family. DLK shares homology with invertebrate homeotic proteins, including Delta and Notch, which are proteins that mediate normal neural differentiation in Drosophila. In mammalian preadipocytes, multiple discrete forms of DLK protein are present due to N-linked glycosylation. DLK is expressed in tumors with neuroendocrine features, such as neuroblastoma and pheochromocytoma cell lines. Normal tissue expression is restricted to the adrenal gland and placenta. Protein-protein interaction between DLK proteins belonging to the same or to different cells, or the interaction between soluble and membrane DLK variants, may be important in regulation of DLK function.
Description: Rabbit polyclonal to DLK1
Immunogen: KLH conjugated synthetic peptide derived from DLK1
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 41 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
