Background: Copper is an essential micronutrient used as a cofactor for several essential enzymes in all living organisms. Due to the high toxicity of copper, its metabolism is tightly regulated and defects in this regulation can cause Menkes (deficiency) or Wilson (accumulation) disease in various tissue. COMMD1(copper metabolism MURR1 domain-containing protein 1), also known as MURR1, is a 190 amino acid protein responsible for inhibition of TNF-induced NFκB p50 and has a suggested role in facilitation of biliary copper excretion within hepatocytes. COMMD1 localizes to both the nucleus and cytoplasm within the cell. Highest expression is found in liver tissue, with lower expressions in lung, heart, kidney and brain tissue. COMMD1 interacts directly with COMMD6 and ATP7B and indirectly with IκB-β and COMMD7. All ten members of the COMMD family (COMMD1-10) contain a conserved COMM domain which provides an interface for protein-protein interactions.
Description: Rabbit polyclonal to COMMD1
Immunogen: KLH conjugated synthetic peptide derived from COMMD1
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 21 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
