Background: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues. SLPI, secretory leukocyte protease inhibitor, is an enzyme that belongs to the α-1 antitrypsin antiprotein family. Produced by epithelial cells, SLPI resides in parotid secretions, bronchial, nasal and cervical mucus, and seminal fluid. SLPI plays a primary role in the regulation of neutrophil-mediated inflammation. It does so through proteolysis and subsequent inhibition of the leukocyte serine proteases, including the neutrophil and pancreatic proteases. The promoter region of SLPI has been identified as binding site for IRF-1, interferon regulatory factor. Expression of SLPI is inhibited by IRF-1 co-expression, identifying SLPI as a target of IRF-1 regulation. SLPI also functions as a macrophage derived inhibitor of macrophage response to LPS by inhibiting the production of nitric oxide, which suggests the role of SLPI in LPS tolerance.
Description: Rabbit polyclonal to SLPI
Immunogen: KLH conjugated synthetic peptide derived from SLPI
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 14 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
