Background: SerpinA11 (serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 11) is a 422 amino acid secreted protein that belongs to the serpin family. In humans, SerpinA11 is part of a gene cluster, which spans over 370 kb on chromosome 14q32.1 and includes 10 additional members of the Serpin superfamily. All Serpin genes have a significant sequence similarityand most share a common gene structure with one untranslated exon andfour coding exons. Accordingly, it has been proposed that members of the Serpin superfamily evolved from a common ancestral gene through a series of duplication events. The SerpinA11 protein exhibits a restricted expression pattern typical of many serpins: very high expression in normal liver, with more than 30-fold less expression in normal breast, prostate BPH (benign prostate hyperplasia) and breast tumor. The Serpin A11 gene is conserved in chimpanzee, canine, bovine, mouse and rat, and maps to human chromosome 14q32.13.
Description: Rabbit polyclonal to SERPINA11
Immunogen: KLH conjugated synthetic peptide derived from SERPINA11
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 47 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
