Background: This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene. The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. [SUBUNIT] Homodimer, and heterodimer with TJP2/ZO-2 and TJP3/ZO-3. Interacts with CGN/cingulin, CXADR, GJD3, HSPA4 and UBN1 (By similarity). Interacts with occludin, claudins, GJA12 and KIRREL1. Belongs to the MAGUK family.
Description: Rabbit polyclonal to ZO-1
Immunogen: KLH conjugated synthetic peptide derived from ZO-1
Specificity: ·Reacts with Human, Mouse, Dog, Pig and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 190 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/50-500;
·Immunocytochemistry: 1/100-500;
·Optimal working dilutions must be determined by the end user.
