Background: Human Epididymis Protein 4 or HE4 is a small whey acidic polypeptide (WAP) expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumour cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcripted in the epididymis it is secreted as an N glycosylated protein and and has homology with some protease inhibitors including elafin, SLPI and eppin. Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.
Description: Rabbit polyclonal to HE4
Immunogen: KLH conjugated synthetic peptide derived from HE4
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 14 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
