Background: Members of the NFκB family of transcription factors are important in regulating the expression of various cellular and viral genes involved in immune and inflammatory responses, cell survival and stress responses. IL-1, TNFα and other related signaling pathways activate transcription factors through the activation of JNK. The NFκB signaling pathway converges with the signal-induced activation of JNK upstream of IKK. Isolated from the human embryonic kidney (HEK) 293 cell line, Act1 is an IKKγ-associated protein that activates both NFκB and JNK constitutively. Act1, also designated NFκB activator 1 or CIKS (for connection to IKK and SAPK/JNK), may function as a coordinator between two stress-induced signaling pathways.
Description: Rabbit polyclonal to CIKS
Immunogen: KLH conjugated synthetic peptide derived from CIKS
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/200-500. Predicted Mol wt: 65 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100-200;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
