Background: Ras-like expressed in many tissues (Rit) is a member of a subgroup within the larger Ras superfamily of small guanine triphosphatases (GTP-binding proteins). Rit contains a unique effector domain that is similar to same domain in the closely related RIN and Drosophila Ric proteins. Rit is involved in neuronal differentiation, development and regeneration by coupling specific trophic factor signals to sustained activation of the B-Raf/ERK and p38 MAP kinase cascades. Rit also appears to play a critical role in neurotrophin-mediated MAP kinase signaling and has modest transforming ability.
Description: Rabbit polyclonal to RIT2
Immunogen: KLH conjugated synthetic peptide derived from RIT2
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 26 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
