Background: ACAM (adipocyte adhesion molecule), also known as ASAM or CLMP (coxsackie- and adenovirus receptor-like (CAR-) membrane protein), is a 373 amino acid tight junction single-pass type I membrane protein that belongs to the CTX (cortical thymocyte marker in Xenopus) family and is predominantly expressed in epithelial cells and in white adipose tissue. ACAM is upregulated in mature adipocytes and adipocyte tissue of obese individuals. Considered a novel cell-cell adhesion molecule, ACAM is regulated by TTP through the JNK signaling cascade and may be involved in junctional barrier function. ACAM contains a signal peptide, V-type (variable) and C2-type (constant) Ig domains, a single transmembrane segment and a cytoplasmic tail.
Description: Rabbit polyclonal to ASAM
Immunogen: KLH conjugated synthetic peptide derived from ASAM
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 45 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
