Background: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. AQP11 (aquaporin-11), also known as AQPX1, is a 271 amino acid multi-pass membrane protein that belongs to the MIP/aquaporin family and the AQP11/AQP12 subfamily. Encoded by a gene that maps to human chromosome 11q14.1, AQP11 contains three exons and is highly expressed in testis, moderately in thymus, kidney, liver and intestine, and marginally in brain and lung. Similar to other aquaporin family members, AQP11 consists of two tandem repeats, each containing three membrane-spanning domains. However, AQP11 contains one pore-forming loop with an asparagine-proline-alanine (NPA) signature motif distinct from other aquaporins, which typically have two, suggesting that AQP11 is comprised of a different pore structure and performs a unique function. Disruption of AQP11 may be linked to polycystic kidneys, primary proximal tubule defects, hepatic cysts and renal failure.
Description: Rabbit polyclonal to AQP11
Immunogen: KLH conjugated synthetic peptide derived from AQP11
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 26 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
