Background: Dental enamel is a highly mineralized tissue with most of its volume occupied by large, highly organized, hydroxyapatite crystals. This structure is thought to be controlled through the interaction of many organic matrix molecules including amelogenin, ameloblastin, enamelin, tuftelin and several other enzymes. All of these secreted proteins are involved in the mineralization and enamel matrix formation in developing tooth enamel. Enamelin (ENAM) localizes to the extracellular matrix. During the secretory stage of enamel formation, it plays a role in enamel extension. Enamelin is expressed in odontoblasts, cementoblasts and ameloblasts. Defects in the gene encoding for enamelin, ENAM, may cause hypoplastic amelogenesis imperfecta 2 (AIH2) which is an autosomal dominant disease characterized by anomalies in enamel development.
Description: Rabbit polyclonal to Enamelin
Immunogen: KLH conjugated synthetic peptide derived from Enamelin
Specificity: ·Reacts with Human, Mouse, Pig and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 129 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/50-500;
·Immunocytochemistry: 1/100-200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
