Background: CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Description: Rabbit polyclonal to CD130, FITC conjugated
Immunogen: KLH conjugated synthetic peptide derived from CD130
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·FCM: 1/20-100;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/20-200;
·Immunocytochemistry: 1/100-500;
·Excitation spectrum: 490-495nm;
·Emission spectrum: 520-530nm;
·Optimal working dilutions must be determined by the end user.
