Background: EAAT3 transports L-glutamate and also L- and D-aspartate, acting as a symport by cotransporting sodium. EAAT3 is essential for terminating the postsynaptic action of glutamate, by rapidly removing released glutamate from the synaptic cleft. This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect.
Description: Rabbit polyclonal to EAAT3
Immunogen: KLH conjugated synthetic peptide derived from EAAT3
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/200-1000. Predicted Mol wt: 57 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/50-100;
·Immunocytochemistry: 1/100-500;
·Optimal working dilutions must be determined by the end user.
