Background: Neurotrophins function to regulate naturally occuring cell death of neurons during development .The prototype neurotrophin is nerve growth factor (NGF),originally discovered in the 1950s as a soluble peptide promoting the survival of and veurite outgrowth from, sympathetic ganglia. More recently,three additional structurally homologous neurotrophic factor have been identified.These include brain-derived neurotrophic factor (BDNF), neurotrophic-3 (NT-3) neurotrophic-4(NT-4), also designated NT-5. These neurous neurotrophic stimulate the in vitro survival of distinct but partilly overlapping populations of neurons. The Trk A receptor is the preferential receptor for NGF, but also binds NT-3and NT-4. The Trk B receptor binds equally well both BDNF and NT-4, and to a lesser extent NT-3, while the Trk C receptor only binds NT-3.
Description: Rabbit polyclonal to NGF-β
Immunogen: KLH conjugated synthetic peptide derived from NGF-β
Specificity: ·Reacts with Human, Mouse, Pig, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 27 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
