Background: Glypican 3 is a member of the glypican family of heparan sulfate proteoglycans, which attach to the cell membrane via a glycosyl-phosphatidylinositol (GPI) anchor. Expression of glypican-3 is detected in embryonic mesodermal lung, liver and kidney tissues. Glypican 3 is thought to regulate tissue and organ growth through interactions with growth factors such as Insulinlike growth factor II (IGF-II) or fibroblast growth factor 2 (FGF-2). Glypican 3 may be downregulated by various means, including promoter hypermethylation or the repression of specific transcription factors. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome.
Description: Rabbit polyclonal to Glypican 3
Immunogen: KLH conjugated synthetic peptide derived from Glypican 3
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 66 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
