Background: Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. Also known as: downstream of tyrosine kinase 1; docking protein 1; Docking protein 1; docking protein 1 62kD; DOK 1; P62DOK; pp62.
Description: Rabbit polyclonal to DOK-1
Immunogen: KLH conjugated synthetic peptide derived from DOK-1
Specificity: ·Reacts with Human, Mouse, Pig, Cow, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 62 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/100-500;
·ELISA: 1/1000;
· Optimal working dilutions must be determined by the end user.
