Background: The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors and, based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens and are expressed in tumors of different histologic types and in normal testis and placenta. MAGE-A12 (melanoma-associated antigen 12), also known as MAGE12 or CT 1.12 (cancer/testis antigen 1.12), is a 314 amino acid protein that contains one MAGE domain and is thought to play a role in tumor progression. Like other members of the MAGE family, MAGE-A12 is expressed in head and neck squamous cell carcinoma, melanoma, breast cancer and lung cancer, suggesting that MAGE-A 12 plays an important role in carcinogenesis.
Description: Rabbit polyclonal to MAGEA12
Immunogen: KLH conjugated synthetic peptide derived from MAGEA12
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 35 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
