Background: Synaptic nuclear envelope protein 2 (Syne-2), also referred to as nesprin-2, is a 6,884 amino acid vertebrate protein that interacts with emerin and Lamin A at the nuclear envelope. Syne-2 is highly expressed in kidney, liver, stomach, placenta, spleen, lymphatic nodes and peripheral blood lymphocytes, but can be found in almost all types of cells. Syne-2 contains a C-terminal transmembrane domain (designated the KLS domain) linked by a spectrin-repeat rod domain to an N-terminal paired, Actin-binding, calponin-homology domain. This structure suggests that Syne-2 is capable of mediating signaling between cell membranes and the cytoskeleton. The Syne-2 gene gives rise to many isoforms, which vary largely in size. Mutations in the Syne-2 gene may be linked to a broad range of human diseases, including laminopathies.
Description: Rabbit polyclonal to Nesprin 2
Immunogen: KLH conjugated synthetic peptide derived from Nesprin 2
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 75 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
