Background: GPR63 (Probable G-protein coupled receptor 63, PSP24b) is a 419 amino acid protein encoded by the human GPR63 gene. GPR63 is an orphan receptor member of the G-protein coupled receptor 1 family. G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. Key roles for G protein-coupled receptors include control of protein maturation and cell surface delivery and providing the correct framework for interactions with both heterotrimeric G proteins and arrestins to allow signal generation and its termination. GPR63 is expressed in brain tissue, most notably frontal cortex, with lower levels in the thalamus, caudate, hypothalamus and midbrain.
Description: Rabbit polyclonal to GPCR GPR63
Immunogen: KLH conjugated synthetic peptide derived from GPCR GPR63
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 48 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
